Postdocalypse

Postdocalypse Later, Part 2

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Postdocalypse

Postdocalypse later

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Ghostbusters movie image Harold Ramis, Bill Murray and Dan Aykroyd

Indie science update

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PhD comic

My postdoc research proposal

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goals vs donors_min

The science crowdfunding landscape

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HandbookForTheRecentlyDeceased

Handbook for the academically deceased

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mouse_featured image

Off mice and men

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Yeast de résistance overdose-resistance selections

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Yeast de résistance #5

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30C incubator

Yeast de résistance #4

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Microryza campaign trajectories

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the-ugly-duckling

We are all n=1 now

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mystery drug

Yeast de résistance #3

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Life Scientist Goes Indie: Ethan Perlstein

July 2013 Mendelspod interview

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Figure 1

Npc1 acting in neurons and glia is essential for the formation and maintenance of CNS myelin

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Ethan Perlstein discusses Carlsbad's community biotech center

Brief interview about new SoCal biotech hackubator

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yeast part deux

Yeast de résistance, part deux

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The science of crowdfunding

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npc fly model

A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis

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indie science update

Indie science

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shmoo2

Genus envy

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moon shot

Time for a rare disease Moon Shot?

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figure 2_loftus

Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene

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C4D spring update featured

Crowd4Discovery Spring update

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S2-8-400uM-newRapa-overlay-03

Crowd4Discovery striatal primary neuronal culture experiment 2

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S2-1-control-overlay-01

Crowd4Discovery striatal primary neuronal culture experiment 1

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lab notebook

Crowd4Discovery protocols and experimental summaries

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Needle-In-A-Haystack

Rare disease diagnosis and drug discovery

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featured

Molecular Mechanisms of Drug Action: An Emerging View

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npc fibro

Cultured Skin Fibroblasts in Storage Disorders

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yeast de resistance

Yeast de résistance

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lsd fish

Characterization of behavioral and endocrine effects of LSD on zebrafish

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venkman

Back off, man. I’m an independent scientist

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wrench

Crowd4Discovery March update

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hungergames

The Tenure Games

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Figure 1

Drosophila Niemann-Pick type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease

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hybrid vigor

Hybrid business model vigor

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lionness

cri de cure

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Ventral midbrain neuronal cultured treated with 50µM amphetamine for 24 hours

Crowd4Discovery update: February 2013

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CFTRmodel

Rare Disease Day 2013: cystic fibrosis

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Insights into cell membranes via dish detergent - Ethan Perlstein

Ted-Ed membrane lesson

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MOOC

Adventures in pedagogy

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NPR: Morning Edition

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VM1A-1_steady_overlay_09b

Crowd4Discovery autophagy experiment 1

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sert mutant

How do antidepressants actually work?

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lyso

Cationic amphiphilic drugs cause a marked expansion of apparent lysosomal volume

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Ethan Perlstein "Crowdsourcing Science Funding"

LucidNYC talk

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postdocalypse now

Postdocalypse now

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CSDmicroZoom

A preview of Crowd4Discovery experiments

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twitter _modclasses

The role of Twitter in our crowdfunding success

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VPL

Protein sorting in yeast: mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway

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Twitter donor subgraphs

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twitter-icon-18

The demographics of science crowdfunders

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PAC

The Academia-Pharma Complex

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bilayer couple fig 1

Biological Membranes as Bilayer Couples. A Molecular Mechanism of Drug-Erythrocyte Interactions

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total raised over time

Anatomy of a crowdfund: after the dust settled

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Facebook donor subgraphs

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CSDRocketLAUNCH

You just crowdfunded a research meth lab!

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PostitPress

Anatomy of a crowdfund: the homestretch

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FB network_modularity classes

Anatomy of a crowdfund, week 5: content or connection?

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FB network

Can your Facebook network finance your dream project?

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7cows

Anatomy of a crowdfund, week 4: feast or famine

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thetortoisethehare

Anatomy of a crowdfund, week 3: slow and steady

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EthanPortraitd

Anatomy of a crowdfund, week 2: branding and networks

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the peanut gallery

The peanut gallery

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exercise

Genetercise class

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donation lolcat

Anatomy of a crowdfund, week 1

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meth mouth

Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis

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BeekerBreaking

The first 96 hours after launch

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Crowdsourcing Discovery

Crowdsourcing Discovery

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meth_autorad*

Distribution and marketing

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DNA-sodoku

Papers as puzzles

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Yeast cell vacuole portrait gallery

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teaching

A paper-based approach to undergraduate biology

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021012-4716-steady_041 (whorl)

The vacuole life cycle of yeast series, cell #4

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Crystal blue persuasion

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breakingbad*

Meth is a weak base, yo

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reheated mug

Fall crowdfund drive

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breaking-bad-lab

Crowdfund my meth lab, yo

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Epcot

This is crazy but here’s my preprint, so arXiv maybe

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Age Distribution of NIH Principal Investigators and Medical School Faculty

Age Distribution of NIH Principal Investigators and Medical School Faculty

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Figure 8

Evolutionarily Repurposed Networks Reveal the Well-Known Antifungal Drug Thiabendazole to Be a Novel Vascular Disrupting Agent

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global distribution

Quantified Self Publishing

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RSA Animate - The Divided Brain

Scientist-Artist Collaboration

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show-me-the-money

How much does it cost to run an academic lab? (Part 2)

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LipidVesicle13

Watson & Crick, sure. What about Gorter & Grendel?

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FY2010 breakdown

How much does it cost to run an academic lab?

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RBC_sertraline_3.75µM sertraline

The bilayer couple model in action

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scienceportals

Crowdfunding Science 101

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Publishing in the Era of Open Science, Part 2

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phenothiazine

Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells

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fig1

Evidence for the neurogenesis hypothesis of depression?

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returntosender

If you email it, they will comment

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bilayerthickening

Drug accumulation thickens cell membrane

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phospholipidosis

Psychopharmacology’s blind spot

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lipiddroplet

What’s going on with this lipid droplet?

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Princeton researcher hopes to reinvent medical research lab web sites

Princeton researcher hopes to reinvent medical research lab web sites

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hexagonalphasev2

Hexagonal and multilamellar phospholipid phases

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map

Google Analyze This

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backtobasics-featured

Back to bases

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crowdfunding

Start me up

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antipsychotics

Use-Dependent Inhibition of Synaptic Transmission by the Secretion of Intravesicularly Accumulated Antipsychotic Drugs

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Evolutionary Pharmacology Explained

Evolutionary Pharmacology Explained

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bilayer_expansion

Is this bilayer expansion?

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The Antidepressant Sertraline Targets Intracellular Vesiculogenic Membranes in Yeast

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Do Worms Get Depressed?

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Lipid Droplet Census

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Whence Evolutionary Pharmacology

Whence Evolutionary Pharmacology

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figshare

Share Your Data!

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Transgenic elimination of high-affinity antidepressant and cocaine sensitivity in the presynaptic serotonin transporter

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Antidepressant Drugs Transactivate TrkB Neurotrophin Receptors in the Adult Rodent Brain Independently of BDNF and Monoamine Transporter Blockade

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Accumulation of an Antidepressant in Vesiculogenic Membranes of Yeast Cells Triggers Autophagy

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Statement of Teaching Philosophy

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Autophagy In Action

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Publishing in the Era of Open Science

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Drug Resistance

A Brief History of Drug Resistance

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Lipid Phase Transitions

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zoloft.fw

The Path of Yeast Resistance

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