I saw this study, it’s really cool. Interestingly, there are two NPC genes in C. elegans, ncr-1 and ncr-2, and they are functionally equivalent for the purposes of cholesterol uptake. I’m not sure which one is more similar to NPC2, but we have an assay that distinguishes them in vivo. It’s one of the many stalled projects waiting for someone to adopt it in the lab.
We should definitely figure out a way to collaborate on this. Niemann-Pick is one of the lysosomal storage disorders that can be modeled in yeast, worms and flies.