Drosophila Niemann-Pick type C-2 genes control sterol homeostasis and steroid biosynthesis: a model of human neurodegenerative disease

March 24, 2013

Related Posts

Genus envy
Do Worms Get Depressed?
Yeast de résistance #5
  • http://twitter.com/DrWorms Brian D. Ackley

    I saw this study, it’s really cool. Interestingly, there are two NPC genes in C. elegans, ncr-1 and ncr-2, and they are functionally equivalent for the purposes of cholesterol uptake. I’m not sure which one is more similar to NPC2, but we have an assay that distinguishes them in vivo. It’s one of the many stalled projects waiting for someone to adopt it in the lab.

    • http://twitter.com/eperlste Ethan Perlstein

      We should definitely figure out a way to collaborate on this. Niemann-Pick is one of the lysosomal storage disorders that can be modeled in yeast, worms and flies.